Journal
CELL ADHESION & MIGRATION
Volume 10, Issue 6, Pages 700-708Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/19336918.2016.1261785
Keywords
semaphorin signaling; neuropilin; plexin; targeted therapies
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Funding
- French government [LABEX ANR-10-LABX-0034_Medalis]
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The Semaphorin/Neuropilin/Plexin (SNP) complexes control a wide range of biological processes. Consistently, activity deregulation of these complexes is associated with many diseases. The increasing knowledge on SNP had in turn validated these molecular complexes as novel therapeutic targets. Targeting SNP activities by small molecules, antibodies and peptides or by soluble semaphorins have been proposed as new therapeutic approach. This review is focusing on the latest demonstration of this potential and discusses some of the key questions that need to be addressed before translating SNP targeting into clinically relevant approaches.
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