Journal
CANCER GENETICS
Volume 209, Issue 9, Pages 388-394Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cancergen.2016.08.003
Keywords
Mir-27a; colorectal cancer; polymorphism; meta-analysis
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Funding
- National Natural Science Foundation of China [81402743, 81302491, 81172752]
- Hubei Province Health and Family Planning Scientific Research Project [WJ2015Q023]
- Fundamental Research Funds for the Central Universities [2042016kf0165]
- Doctoral Scientific Fund Project of the Ministry of Education of China [20130142120021]
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Colorectal cancer (CRC) is the most common malignancy in the human digestive system. Previous results regarding the association between microRNA-27a rs895819 polymorphisms and CRC risk are controversial. We therefore performed a meta-analysis of seven studies totaling 2230 cases and 2775 controls to systematically evaluate this association. Summary odds ratios (ORs) and 95% confidence intervals (Cls) were obtained using a fixed-effects model. A moderate evidence for the association between mir-27a polymorphism and CRC risk was found under multiple genetic models (dominant model: OR = 1.15, 95% CI: 1.02-1.29, p = 0.02; recessive model: OR = 1.49, 95% CI: 1.27-1.76, p < 0.001; homozygote model: OR = 1.53, 95% CI: 1.28-1.83, p < 0.001; allele model: OR = 1.21, 95% CI: 1.11-1.31, p < 0.001). Subgroup analysis showed a significant association between mir-27a rs895819 polymorphism and CRC risk among Chinese populations. On the contrary, we found no evidence of association among Caucasian populations due to small samples (p > 0.05). In conclusion, this meta-analysis suggested that rs895819 polymorphism in mir-27a may be a potential genetic risk factor for CRC, particularly in Chinese populations.
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