Journal
BIOMEDICAL OPTICS EXPRESS
Volume 7, Issue 12, Pages 5129-5137Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.7.005129
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Funding
- Fonds de recherche du Quebec - Nature et technologies (FRQNT)
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Canadian Institutes of Health Research (CIHR)
- Groupe de Recherche en Sciences et Technologies (GRSTB)
- Banque Nationale
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Surgical treatment of brain cancer is limited by the inability of current imaging capabilities such as magnetic resonance imaging (MRI) to detect the entirety of this locally invasive cancer. This results in residual cancer cells remaining following surgery, leading to recurrence and death. We demonstrate that intraoperative Raman spectroscopy can detect invasive cancer cells centimeters beyond pathological T1-contrast-enhanced and T2-weighted MRI signals. This intraoperative optical guide can be used to detect invasive cancer cells and minimize post-surgical cancer burden. The detection of distant invasive cancer cells beyond MRI signal has the potential to increase the effectiveness of surgery and directly lengthen patient survival. (C) 2016 Optical Society of America
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