Journal
BIOMEDICAL OPTICS EXPRESS
Volume 7, Issue 4, Pages 1311-1322Publisher
Optica Publishing Group
DOI: 10.1364/BOE.7.001311
Keywords
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Funding
- National Science Foundation [CBET-1509218]
- University of California Cancer Research Coordinating Committee [5-44189-34912]
- Office of Research and Economic Development at the University of California, Riverside (UCR)
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Constructs derived from mammalian cells are emerging as a new generation of nano-scale platforms for clinical imaging applications. Herein, we report successful engineering of hybrid nano-structures composed of erythrocyte-derived membranes doped with FDA-approved near infrared (NIR) chromophore, indocyanine green (ICG), and surface-functionalized with antibodies to achieve molecular targeting. We demonstrate that these constructs can be used for targeted imaging of cancer cells in vitro. These erythrocyte-derived optical nano-probes may provide a potential platform for clinical translation, and enable molecular imaging of cancer biomarkers. (C) 2016 Optical Society of America
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