Journal
BIOMEDICAL OPTICS EXPRESS
Volume 8, Issue 1, Pages 243-259Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.8.000243
Keywords
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Funding
- UK Engineering and Physical Sciences Research Council [EP/K03197X/1]
- EPSRC [EP/K03197X/1, EP/M507258/1] Funding Source: UKRI
- MRC [G0901697, MR/L012766/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/M507258/1, EP/K03197X/1] Funding Source: researchfish
- Medical Research Council [MR/L012766/1, G0901697] Funding Source: researchfish
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Previously unobtainable measurements of alveolar pH were obtained using an endoscope-deployable optrode. The pH sensing was achieved using functionalized gold nanoshell sensors and surface enhanced Raman spectroscopy (SERS). The optrode consisted of an asymmetric dual-core optical fiber designed for spatially separating the optical pump delivery and signal collection, in order to circumvent the unwanted Raman signal generated within the fiber. Using this approach, we demonstrate a similar to 100-fold increase in SERS signal-tofiber background ratio, and demonstrate multiple site pH sensing with a measurement accuracy of +/- 0.07 pH units in the respiratory acini of an ex vivo ovine lung model. We also demonstrate that alveolar pH changes in response to ventilation. (C) 2016 Optical Society of America
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