Journal
BIOMEDICAL OPTICS EXPRESS
Volume 7, Issue 2, Pages 499-511Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.7.000499
Keywords
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Funding
- National Natural Science Foundation of China [81271618, 81371602, 61475115, 61475116, 81401453, 61575140, 81571723]
- Tianjin Municipal Government of China [13JCZDJC28000, 14JCQNJC14400, 15JCZDJC31800]
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We implemented a novel lock-in photon-counting detection architecture that combines the ultra-high sensitivity of the photon-counting detection and the measurement parallelism of the lock-in technique. Based on this technique, a dual-wavelength simultaneous measurement continuous wave diffuse optical tomography system was developed with a configuration of 16 sources and 16 detectors that works in a tandem serial-to-parallel fashion. Methodology validation and performance assessment of the system were conducted using phantom experiments that demonstrate excellent measurement linearity, moderate-term system stability, robustness to noise and negligible inter-wavelength crosstalk. 2-D imaging experiments further validate high sensitivity of the lock-in photon-counting methodology as well as high reliability of the proposed system. The advanced detection principle can be adapted to achieving a fully parallelized instrumentation for the extended applications. (C) 2016 Optical Society of America
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