Journal
BIOMEDICAL OPTICS EXPRESS
Volume 7, Issue 9, Pages 3596-3609Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.7.003596
Keywords
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Funding
- Connaught Fund [498042]
- MITACS [IT02018]
- National Sciences and Engineering Research Council (NSERC) [RGPIN-355623-08]
- Canadian Institutes of Health Research (CIHR) [CPG-121050]
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We report on a miniature label-free imaging system for monitoring brain blood flow and blood oxygenation changes in awake, freely behaving rats. The device, weighing 15 grams, enables imaging in a similar to 2 x 2 mm field of view with 4.4 mu m lateral resolution and 1-8 Hz temporal sampling rate. The imaging is performed through a chronically-implanted cranial window that remains optically clear between 2 to > 6 weeks after the craniotomy. This imaging method is well suited for longitudinal studies of chronic models of brain diseases and disorders. In this work, it is applied to monitoring neurovascular coupling during drug-induced absence-like seizures 6 weeks following the craniotomy. (C) 2016 Optical Society of America
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