Journal
BIOMEDICAL OPTICS EXPRESS
Volume 7, Issue 10, Pages 4346-4363Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.7.004346
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- LASERLAB-EUROPE [654148]
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Simulations and phantom measurements are used to evaluate the ability of time domain diffuse optical tomography using Mellin-Laplace transforms to quantify the absorption perturbation of centimetric objects immersed at depth 1-2 cm in turbid media. We find that the estimated absorption coefficient varies almost linearly with the absorption change in the range of 0-0.15 cm(-1) but is underestimated by a factor that depends on the inclusion depth (similar to 2, 3 and 6 for depths of 1.0, 1.5 and 2.0 cm respectively). For larger absorption changes, the variation is sublinear with similar to 20% decrease for delta mu(a) = 0.37 cm(-1). By contrast, constraining the absorption change to the actual volume of the inclusion may considerably improve the accuracy and linearity of the reconstructed absorption. (C) 2016 Optical Society of America
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