Journal
ARABIAN JOURNAL OF CHEMISTRY
Volume 12, Issue 8, Pages 4920-4946Publisher
ELSEVIER
DOI: 10.1016/j.arabjc.2016.10.009
Keywords
Anticancer; Quinoline; Quinoline derivatives; Structure-activity relationship
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Funding
- Uttar Pradesh University of Medical Sciences
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Among heterocyclic compounds, quinoline scaffold has become an important construction motif for the development of new drugs. Quinoline and its derivatives possess many types of biological activities and have been reported to show significant anticancer activity. Quinoline compounds play an important role in anticancer drug development as they have shown excellent results through different mechanism of action such as growth inhibitors by cell cycle arrest, apoptosis, inhibition of angiogenesis, disruption of cell migration and modulation. A number of quinoline derivatives have been reported till date for their anticancer activity. The present review, summarizes various mono-, di-, tri-, tetra- and heterocyclic substituent quinoline derivatives with potential anticancer activity. Their mechanism of action and possible structure activity relationship has also been discussed. (C) 2016 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.
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