Synthesis, antibacterial and antifungal activity of novel benzothiazole pyrimidine derivatives

A new series of 5-amino-6-(benzo[d]thiazol-2-y1)-2-(2-(substitutedbenzylidene)hydrazinyl)-7-(4-chlorophenyl)pyrido[2,3-4pyrimidin-4(3H)-one derivatives (7a-k) were synthesized. All the newly synthesized compounds were screened for their in vitro antibacterial activity, against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Streptococcus pyogenes and for antifungal activity against Aspergillus flavus, Aspergillus fiimigatus, Candida albicans, Penicillium marneffei and Mucor. Compounds 7b, 7e, 7f, 7g, 7h and 7j showed excellent in vitro antibacterial activity and antifungal activity than the standard drugs. All the compounds were characterized by IR, H-1 NMR, C-13 NMR, LCMS mass and C, H, N analyses. (C) 2013 Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license.