Journal
ARABIAN JOURNAL OF CHEMISTRY
Volume 9, Issue -, Pages S1928-S1934Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.arabjc.2014.10.017
Keywords
Danofloxacin; Labeling; Technetium; Inflammation; Infection; Diagnosis
Categories
Funding
- Deanship of Scientific Research at Prince Sattam Bin Abdulaziz University [2015/01/5126]
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Danofloxacin, a fluoroquinolone derivative antibiotic, was synthesized, successfully labeled with technetium-99m and formulated for the development of a potential diagnostic imaging agent of the bacterial infection and inflammation with higher efficiency than that of the commercially available Tc-99m-ciprofloxacin. Factors affecting the labeling yield were optimized. The radiolabeled antibiotic was subjected to preclinical assessments such as purity, stability, and pharmacokinetic investigations in animals. The biodistribution studies indicated that the uptake of Tc-99m-danofloxacin was high in the infectious lesion (T/NT = 7.2 +/- 0.1) at 2 h post injection. The abscess to normal ratio indicated that the danofloxacin tracer can be used for infection diagnosis. The radiolabeled compound was cleared quickly from most of the body organs. The results displayed that Tc-99m-danofloxacin could not differentiate between infection and sterile inflammation. (C) 2014 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.
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