Journal
ACS CATALYSIS
Volume 6, Issue 8, Pages 5561-5564Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.6b01413
Keywords
copper catalyst; amides synthesis; carbonylation; amines; alkanes
Categories
Funding
- Chinese Scholarship Council
- NSFC [21472174]
- Zhejiang Natural Science Fund for Distinguished Young Scholars [LR16B020002]
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Amides are important intermediates and building blocks in organic synthesis. Among the known preparation procedures, aminocarbonylation is an interesting and powerful tool. However, most of the studies were focused on noble metal-catalyzed synthesis of aromatic amides. Herein, we describe an attractive copper-catalyzed synthesis of aliphatic amides from alkanes and amines. A variety of amides were prepared in good yields by carbonylation of the C-(sp3)-H bond of alkanes with different amines. Good functional groups tolerance can be observed.
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