Journal
ACS CATALYSIS
Volume 6, Issue 10, Pages 6546-6550Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.6b02218
Keywords
cobalt; pincer complex; catalysis; secondary amine; H-borrowing
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Funding
- American Chemical Society [54247-UNI3]
- CUNY Collaborative Research Incentive Program
- PSC-CUNY award [69069-0047]
- Office for the Advancement of Research at John Jay College, CUNY
- National Science Foundation [CHE-1464543]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1464543] Funding Source: National Science Foundation
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The replacement of precious metals with inexpensive, less toxic, and earth-abundant elements in typical noble-metal-mediated organic transformations is a major goal in current synthetic chemistry and industries. The metal-catalyzed N-alkylation of amines with other amines through a hydrogen-borrowing principle represents a green and atom economical reaction for the synthesis of secondary amines. However, catalysts developed thus far that are effective for this process remain quite scarce and are only limited to a few ruthenium and iridium complexes. In this work, we present a cobalt-catalyzed selective alkylation of amines with amines to synthesize a large variety of secondary amines. A range of amine substrates have been converted to the corresponding products through hetero- or homocoupling between amines. Cyclic sec-amines are also achieved from diamine precursors as rare examples.
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