Journal
ACS CATALYSIS
Volume 6, Issue 4, Pages 2482-2486Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.6b00294
Keywords
aldol reaction; allenes; asymmetric catalysis; carbinol allenoates; gold catalysis
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Funding
- National Natural Science Foundation of China [21432006, 21321061, 21372162]
- Fok Ying Tung Education Foundation [141115]
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A new asymmetric alleno-aldol addition of allenic esters has been developed that allows the formation of trisubstituted and tetrasubstituted carbinol allenoates diastereoselectively and enantioselectively. The nucleophilic additions of achiral and racemic alienates to isatins proceed well in the presence of AuCl3 and chiral N,N'-dioxide under mild reaction conditions. The results reported herein represent the first example of metal complex promoted gamma-selective asymmetric addition of allenic esters to carbonyl compounds.
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