Journal
ACS CATALYSIS
Volume 7, Issue 1, Pages 438-442Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.6b03222
Keywords
bioconjugation; immobilization; lipase; metal organic frameworks; multifunctionalization; post-synthetic modification; surface modification
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Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [2010-0022069]
- Ministry of Science, ICT, and Future Planning [2014R1A2A2A01004836]
- National Research Foundation of Korea [2010-0022069] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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One of the most attractive characteristics of metal organic frameworks (MOFs) is their diversity in use as functional materials, because their diversity means that the appropriate MOFs for the required applications can be readily generated from numerous elemental compounds. In addition, post-synthetic modifications of MOFs further expand their diversity. We describe a combined approach involving a typical post-synthetic modification and our previously reported surface modification to introduce multicompounds on MOFs. This method has been used to alter the local environments of a target biocatalyst and has enhanced the activity of the biocatalyst in polar organic media. It has been known that lipases are more active in nonpolar organic solvents than in polar ones. Hence, it can be hypothesized that surrounding lipase molecules with nonpolar compounds possibly increases the activity of lipases in polar organic solvents such as acetonitrile. A series of fatty acids (C12-C22) were conjugated with the amino groups of 2-amino-1,4-benzene dicarboxylate (NH2-BDC) in UiO-66-NH2 (ZrMOF) and then Candida antarctica lipase B (CAL-B) was covalently bonded to the pendent carboxylate groups on the surface of ZrMOF. The introduction of fatty acids around the covalently conjugated CAL-B molecules on ZrMOF improved the activity in acetonitrile by a factor of up to 13.
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