Journal
ACS CATALYSIS
Volume 7, Issue 1, Pages 93-97Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.6b02959
Keywords
amination; borrowing hydrogen; acid catalysis; amino alcohol; enantioselectivity
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Funding
- Singapore National Research Foundation [R-143-000-477-281, R-143-000-606-281]
- Ministry of Education (MOE) of Singapore [R-143-000-613-112]
- National Natural Science Foundation of China [21502082]
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Here, we present a highly enantioselective synthesis of 1,2-amino alcohols from readily available racemic 1,2-diols through a borrowing hydrogen process. An intriguing acid effect was discovered for this Ru-catalyzed amination reaction, which led to a significant improvement of the stereoselectivity of the process. Preliminary mechanistic studies suggest a scenario of Bronsted acid-assisted dynamic kinetic asymmetric amination of alcohols.
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