Journal
ACS CATALYSIS
Volume 6, Issue 11, Pages 7448-7451Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.6b02114
Keywords
iron catalysis; cross coupling; allenol; allenyl acetate; Grignard reagents
Categories
Funding
- European Research Council [ERC AdG 247014]
- Swedish Research Council [621-2013-4653]
- Berzelii Centre EXSELENT
Ask authors/readers for more resources
alpha-Allenols are attractive and versatile compounds whose preparation can be a nontrivial task. In this Letter, we provide a method for the prompt synthesis of substituted alpha-allenols via a catalytic cross-coupling reaction which makes use of a nontoxic and cost-effective iron catalyst. The catalyst loading is typically as low as 1-5 mol %. The mild reaction conditions (-20 degrees C) and the short reaction time (15 min) allow for the presence of a variety of functional groups. Moreover, the reaction was shown to be scalable up to gram scale and the propargyl substrates are readily accessible by a one-pot synthesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available