Journal
NATURE COMMUNICATIONS
Volume 7, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms12209
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Funding
- European Research Council (Project 'lincSAFARI')
- Israeli Science Foundation [1242/14, 1984/14, 1796/12]
- I-CORE Program of the Planning and Budgeting Committee
- Minerva Foundation
- Fritz-Thyssen Foundation
- Abramson Family Center for Young Scientists
- Henry Chanoch Krenter Institute for Biomedical Imaging and Genomics
- Leir Charitable Foundations
- Richard Jakubskind Laboratory of Systems Biology
- Cymerman-Jakubskind Prize
- Lord Sieff of Brimpton Memorial Fund
- Human Frontiers Science Program
- European Molecular Biology Organization Young Investigator Program
- European Research Council under the European Union's Seventh Framework Programme (FP7)/ERC grant [335122]
- Alon Fellowship
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Thousands of long noncoding RNA (lncRNA) genes are encoded in the human genome, and hundreds of them are evolutionarily conserved, but their functions and modes of action remain largely obscure. Particularly enigmatic lncRNAs are those that are exported to the cytoplasm, including NORAD-an abundant and highly conserved cytoplasmic lncRNA. Here we show that most of the sequence of NORAD is comprised of repetitive units that together contain at least 17 functional binding sites for the two mammalian Pumilio homologues. Through binding to PUM1 and PUM2, NORAD modulates the mRNA levels of their targets, which are enriched for genes involved in chromosome segregation during cell division. Our results suggest that some cytoplasmic lncRNAs function by modulating the activities of RNA-binding proteins, an activity which positions them at key junctions of cellular signalling pathways.
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