Journal
NATURE COMMUNICATIONS
Volume 7, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms11158
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Funding
- Japan Society for the Promotion of Science (JSPS)
- Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT)
- Ono Medical Research Foundation
- Grants-in-Aid for Scientific Research [26107704, 16K15115, 26293016, 15H05931, 16K18872, 26114009, 26111007] Funding Source: KAKEN
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Recent studies suggest that adult humans have active brown or beige adipocytes, the activation of which might be a therapeutic strategy for the treatment of diverse metabolic diseases. Here we show that the protein kinase ASK1 regulates brown and beige adipocytes function. In brown or white adipocytes, the PKA-ASK1-p38 axis is activated in response to cAMP signalling and contributes to the cell-autonomous induction of genes, including Ucp1. Global and fat-specific ASK1 deficiency leads to impaired metabolic responses, including thermogenesis and oxygen consumption, at the cell and whole-body levels, respectively. Our data thus indicate that the ASK1 signalling axis is a regulator of brown and beige adipocyte gene expression and function.
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