Journal
NATURE COMMUNICATIONS
Volume 7, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms11100
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Funding
- RIKEN Brain Science Institute
- KAKENHI [22500285, 26282217, 25116504, 24111509, 15H1275, 21500379, 25111703, 15K18330, 20220007, 25221002, 23650171, 25640017, 23115522, 26117520]
- Regional Innovation Cluster Program
- Human frontier science program (HFSP) [RGP0036/2014]
- program for Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS) from Ministry of Education, Culture, Sports Science, MEXT
- Japan Agency for Medical Research and Development, AMED
- JST International Cooperative Research Project Solution Oriented Research for Science and Technology
- FIRST Program
- Council for Science and Technology Policy
- Grants-in-Aid for Scientific Research [21500379, 26640002, 26282217, 26117520, 24111509, 22500285, 15H05723, 25640017, 15K18330, 25111703, 26115504, 23650171, 15H01275, 25116504] Funding Source: KAKEN
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Transcranical direct current stimulation (tDCS) is a treatment known to ameliorate various neurological conditions and enhance memory and cognition in humans. tDCS has gained traction for its potential therapeutic value; however, little is known about its mechanism of action. Using a transgenic mouse expressing G-CaMP7 in astrocytes and a subpopulation of excitatory neurons, we find that tDCS induces large-amplitude astrocytic Ca2+ surges across the entire cortex with no obvious changes in the local field potential. Moreover, sensory evoked cortical responses are enhanced after tDCS. These enhancements are dependent on the alpha-1 adrenergic receptor and are not observed in IP(3)R2 (inositol trisphosphate receptor type 2) knockout mice, in which astrocytic Ca2+ surges are absent. Together, we propose that tDCS changes the metaplasticity of the cortex through astrocytic Ca2+/IP3 signalling.
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