Journal
NATURE COMMUNICATIONS
Volume 7, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms10476
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Funding
- DOE Office of Science User Facility [DE-AC02-05CH11231]
- Office of Science of the US Department of Energy [DE-AC02-05CH11231]
- US Department of Energy (DOE) [DE-EE-0000716]
- US Department of Energy Joint Genome Institute [CSP-182]
- NASA Exobiology grant [EXO-NNX11AR78G]
- US National Science Foundation [OISE 0968421]
- Key Project of International Cooperation by the Chinese Ministry of Science and Technology (MOST) [2013DFA31980]
- Genome Canada
- Genome Alberta
- Genome BC
- Government of Alberta (GC) [1203]
- DOE [DE-AC52-07NA27344]
- Lawrence Fellowship
- Office Of The Director [0968421] Funding Source: National Science Foundation
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Analysis of the increasing wealth of metagenomic data collected from diverse environments can lead to the discovery of novel branches on the tree of life. Here we analyse 5.2 Tb of metagenomic data collected globally to discover a novel bacterial phylum ('Candidatus Kryptonia') found exclusively in high-temperature pH-neutral geothermal springs. This lineage had remained hidden as a taxonomic 'blind spot' because of mismatches in the primers commonly used for ribosomal gene surveys. Genome reconstruction from metagenomic data combined with single-cell genomics results in several high-quality genomes representing four genera from the new phylum. Metabolic reconstruction indicates a heterotrophic lifestyle with conspicuous nutritional deficiencies, suggesting the need for metabolic complementarity with other microbes. Co-occurrence patterns identifies a number of putative partners, including an uncultured Armatimonadetes lineage. The discovery of Kryptonia within previously studied geothermal springs underscores the importance of globally sampled metagenomic data in detection of microbial novelty, and highlights the extraordinary diversity of microbial life still awaiting discovery.
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