Journal
NATURE COMMUNICATIONS
Volume 7, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms10680
Keywords
-
Categories
Funding
- Danish Council for Independent Research, Medical Research [12-124330, 0602-02914B, 0602-02669B, 4004-00237B, 11-107588]
- Novo Nordisk Foundation
- Lundbeck Foundation [R34-3855, R151-2013-14443]
- Aase og Ejnar Danielsens Fond
- Gigtforeningen
- Oda og Hans Svenningsens Fond
- Fonden til Laegevidenskabens Fremme
- Horslevs Fond
- Danish Council for Independent Research, Natural Science [1323-00218]
- Danish Council for Independent Research [1335-00170, 12-132515]
- The Netherlands Organisation for Scientific Research [916.10.138]
- Dutch Cancer Society [UU 2012-5667]
- Novo Nordisk Fonden [NNF13OC0006211] Funding Source: researchfish
Ask authors/readers for more resources
Stimulator of interferon genes (STING) is known be involved in control of DNA viruses but has an unexplored role in control of RNA viruses. During infection with DNA viruses STING is activated downstream of cGAMP synthase (cGAS) to induce type I interferon. Here we identify a STING-dependent, cGAS-independent pathway important for full interferon production and antiviral control of enveloped RNA viruses, including influenza A virus (IAV). Further, IAV interacts with STING through its conserved hemagglutinin fusion peptide (FP). Interestingly, FP antagonizes interferon production induced by membrane fusion or IAV but not by cGAMP or DNA. Similar to the enveloped RNA viruses, membrane fusion stimulates interferon production in a STING-dependent but cGAS-independent manner. Abolishment of this pathway led to reduced interferon production and impaired control of enveloped RNA viruses. Thus, enveloped RNA viruses stimulate a cGAS-independent STING pathway, which is targeted by IAV.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available