Journal
NATURE COMMUNICATIONS
Volume 7, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms10495
Keywords
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Categories
Funding
- Aase and Ejner Danielsens Foundation
- Academy of Finland
- Agency for Health Care Policy Research
- Ahokas Foundation
- ALFEDIAM
- ALK-Abello A/S (Horsholm, Denmark)
- Althingi (the Icelandic Parliament)
- ANR ('Agence Nationale de la 359 Recherche')
- American Heart Association
- Ardix Medical
- Arthritis Research UK
- Association Diabete Risque Vasculaire, the Federation Francaise de Cardiologie
- AstraZeneca
- Australian Research Council
- Bayer Diagnostics
- BBSRC
- Becton Dickinson
- BMBF (DEEP)
- Boehringer Ingelheim Foundation
- Boston University School of Medicine
- British Heart Foundation
- British Skin Foundation
- Canadian Institutes of Health Research
- Cancer Research UK
- Cardionics
- Centers for Disease Control and Prevention/Association of Schools of Public Health
- Chief Scientist Office of the Scottish Government
- Cohortes Sante TGIR
- CMSB
- CPER ('Contrat de Projets Etat-Region')
- Danish Agency for Science, Technology and Innovation
- Danish Council for Independent Research
- Danish Medical Research Council
- Department of Health, UK
- Deutsche Forschungsgemeinschaft
- Deutshe Forschungsgemeinschaft [SFB992]
- DHFD (Diabetes Hilfs- und Forschungsfonds Deutschland)
- Diabetes UK
- Dutch Dairy Association (NZO)
- Dutch Kidney Foundation
- Dutch Inter University Cardiology Institute Netherlands (ICIN)
- Emil Aaltonen Foundation
- ENGAGE consortium
- Food Standards Agency, UK
- Erasmus Medical Center
- Erasmus University
- Estonian Government
- European Commission
- European Community's Seventh Framework Programme
- European Research Council
- European Research Council [ERC-StG-281641]
- European Union framework program 6 EUROSPAN project
- European Union
- European Union (EU_FP7_NoE 'Epigenesys')
- Faculty of Biology and Medicine of Lausanne
- Federal State of Mecklenburg-West Pomerania
- Federal Ministry of Education and Research (German Obesity Biomaterial Bank)
- Finnish Cardiovascular Research Foundation
- Finnish Centre for Pensions
- Finnish Cultural Foundation
- Finnish Diabetes Research Foundation
- Finnish Diabetes Research Society
- Finnish Foundation for Cardiovascular Research
- Finnish Foundation for Pediatric Research
- Finnish Special Governmental Subsidy for Health Sciences
- Finska Lakaresallskapet
- Folkhalsan Research Foundation
- German Bundesministerium fuer Forschung und Technology
- German Diabetes Association
- German Federal Ministry of Education and Research (Bundesministerium fur Bildung und Forschung, BMBF)
- German Research Council
- GlaxoSmithKline
- Goran Gustafsson Foundation
- Health and Safety Executive, UK
- Helmholtz Zentrum Munchen-German Research Center for Environmental Health
- Hjartavernd (the Icelandic Heart Association)
- Illinois Department of Public Health
- INSERM (Reseaux en Sante Publique, Interactions entre les determinants de la sante)
- Integrated Research and Treatment Centre (IFB)
- Juho Vainio Foundation
- John D and Catherine T MacArthur Foundation Research Networks
- John W. Barton Sr Chair in Genetics and Nutrition
- Kompetenznetz Adipositas
- King's College London
- Knut och Alice Wallenberg Foundation
- Kuopio University Hospital Medical Fund
- Tampere University Hospital Medical Fund
- Turku University Hospital Medical Fund
- Kuopio University Hospital
- La Fondation de France
- Li Ka Shing Foundation
- Liv och Halsa
- Local Government Pensions Institution (KEVA)
- Ludwig-Maximilians-Universitat
- Lundbeck Foundation
- Lundberg Foundation
- Max-Planck Institute
- Medical Research Council, UK
- MEKOS Laboratories Denmark
- Merck Sante
- Ministry for Health, Welfare and Sports, The Netherlands
- Ministry of Cultural Affairs and Social Ministry of the Federal State of Mecklenburg-West Pomerania
- Ministry of Economic Affairs, Agriculture and Innovation, The Netherlands
- Ministry of Education, Culture and Science, The Netherlands
- Ministry of Science, Education and Sport of the Republic of Croatia
- MRC Centre for Causal Analyses in Translational Epidemiology (MRC CAiTE)
- MRC-GlaxoSmithKline
- MRC Human Genetics Unit
- Munich Center of Health Sciences (MC Health)
- Municipality of Rotterdam
- National Center for Advancing Translational Sciences, CTSI
- National Center for Research Resources (NCRR)
- National Genome Research Institute, Korean Center for Disease Control and Prevention
- National Heart Lung and Blood Institute (NHLBI)
- National Heart, Lung and Blood Institute's Framingham Heart Study
- National Institute for Health and Welfare (THL)
- National Institute for Health Research (NIHR)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
- National Institutes of Health
- National Center for Advancing Translational Sciences
- National Institute of Diabetes and Digestive and Kidney Disease Diabetes Research Center (DRC)
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institute on Aging (NIA)
- Netherlands Consortium Healthy Ageing (NCHA)
- Netherlands Genomics Initiative (NGI)
- Netherlands Heart Foundation
- Netherlands Organisation for Scientific Research (NWO)
- Netherlands Organization for the Health Research and Development (ZonMw)
- Novo Nordisk
- Novo Nordisk Foundation
- ONIVINS
- Orion-Farmos Research Foundation
- Paavo Nurmi Foundation
- Pierre Fabre
- Research Centre for Prevention and Health, the Capital Region of Denmark
- Research Institute for Diseases in the Elderly (RIDE)
- Research into Ageing, UK
- Roche
- Royal Swedish Academy of Science
- Russian Foundation for Basic Research
- Sanger Institute
- Samfundet Folkhalsan
- SFD ('Societe Francophone du 358 Diabete')
- Siemens Healthcare
- Signe and Ane Gyllenberg Foundation
- Sigrid Juselius Foundation
- Social Insurance Institution of Finland (KELA)
- State of Bavaria
- Stroke Association, UK
- Swedish Diabetes Foundation
- Swedish Foundation for Strategic Research
- Swedish Heart-Lung Foundation
- Swedish Research Council
- Swedish Research Council for Infrastructures
- Swiss National Science Foundation
- Sylvia AMP
- Charles Viertel Charitable Foundation
- Tampere Tuberculosis Foundation
- Timber Merchant Vilhelm Bangs Foundation
- Topcon
- Torsten and Ragnar Soderberg's Foundation
- Translational Genomics Research Institute
- Unilever UK
- University Cancer Research Fund at UNC Chapel Hill
- University of Eastern Finland
- University of Maryland General Clinical Research Center
- Uppsala University
- Uppsala University Hospital
- USDA National Institute of Food and Agriculture
- VA Clinical Science Research and Development
- Velux Foundation
- VU University Medical Center
- Wageningen University
- Wellcome Trust
- Cancer Research UK [10589, 19167] Funding Source: researchfish
- Lundbeck Foundation [R190-2014-3904] Funding Source: researchfish
- Medical Research Council [MC_PC_U127561128, MR/J010642/1, MC_UU_12015/5, MR/K006584/1, MC_UU_12015/2, MC_UU_12015/1, MR/K013351/1, MC_UU_12013/4, MC_UU_12011/4, MC_U106179471, MC_UP_A100_1003, U1475000003, MR/K002414/1, MC_UP_A620_1016, MR/J012165/1, MC_UU_12011/3, MC_U106179472] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0611-10099, NF-SI-0512-10135, NF-SI-0514-10027] Funding Source: researchfish
- NNF Center for Basic Metabolic Research [Pers Group] Funding Source: researchfish
- Novo Nordisk Fonden [NNF15OC0016220, NNF15OC0016362, NNF12OC1016374, NNF13OC0005785, NNF14OC0010513] Funding Source: researchfish
- MRC [MC_U106179472, MC_UP_A620_1016, MR/J010642/1, MC_UU_12015/2, MR/K002414/1, MC_PC_U127561128, MR/K013351/1, MC_UU_12013/4, MC_UP_A100_1003, MC_UU_12011/3, MC_UU_12011/4, MC_UU_12015/1, MR/J012165/1, MC_UU_12015/5] Funding Source: UKRI
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To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P < 5 x 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
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