4.8 Article

Release of Plasmodium sporozoites requires proteins with histone-fold dimerization domains

Journal

NATURE COMMUNICATIONS
Volume 7, Issue -, Pages -

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms13846

Keywords

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Funding

  1. I-MOVE Fellowship Programme [PCOFUND-GA-2010-267332]
  2. BIOSYS research project, Action KRIPIS - General Secretariat for Research and Technology, Ministry of Education, Greece [MIS-448301 (2013SE01380036)]
  3. European Regional Development Fund
  4. Italian FLAGSHIP 'InterOmics' project - MIUR [PB.P05]
  5. FAPESP [2011/236267]

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The sporozoite, the stage of the malaria parasite transmitted by the mosquito, first develops for similar to 2 weeks in an oocyst. Rupture of the oocyst capsule is required for release of sporozoites, which then transfer to the salivary gland where they are injected into a new host. Here we identify two parasite proteins that we call oocyst rupture proteins 1 (ORP1) and ORP2. These proteins have a histone-fold domain (HFD) that promotes heterodimer formation in the oocyst capsule at the time of rupture. Oocyst rupture is prevented in mutants lacking either protein. Mutational analysis confirms the HFD as essential for ORP1 and ORP2 function, and heterodimer formation was verified in vitro. These two proteins are potential targets for blocking transmission of the parasite in the mosquito.

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