Journal
CLINICAL MICROBIOLOGY AND INFECTION
Volume 21, Issue 3, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cmi.2014.10.009
Keywords
Cellular HIV-DNA; HIV-RNA; naive patients; primary infection; residual viremia
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Funding
- MURST
- Veneto Regional Health Authority [3643/2004, 3499/2008]
- European AIDS Treatment Network (NEAT) (A Network of Excellence EC project) [LSHP-CT-2006-037570]
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In a longitudinal study on 181 naive patients who responded to therapy (mean follow-up 4 years), high baseline human immunodeficiency virus (HIV)-RNA values correlated with high levels of cellular HIV-DNA at all time points (p < 0.0001, p 0.045, p 0.0055, and p 0.0025, respectively) and negatively correlated with undetectable residual viremia (URV; <2.5 copies/mL) at T1, T2, and T3 (p 0.026, p 0.0149, and p 0.0002, respectively). Baseline high HIV-DNA levels predicted the persistence of high values (p 0.0001) and negatively correlated with URV (p 0.0254, p 0.0481, and p 0.0085). These results suggest that baseline viral load, cellular HIV-DNA, and URV were strongly correlated over long-term follow-up of antiretroviral therapy responders. Clinical Microbiology and Infection (C) 2014 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
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