Journal
EPIGENOMICS
Volume 8, Issue 6, Pages 863-879Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2016-0003
Keywords
5-hydroxymethylation; Barker hypothesis; DNMT1; DNMT3A; homocysteine; MeCP2; TET
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Funding
- HSC Research and Development Division of the Public Health Agency, Northern Ireland [STL/5043/14]
- MRC [MR/J007773/1]
- Epigenetics Initiative grant from the ESRC/BBSRC [ES/N000323/1]
- Economic and Social Research Council [ES/N000323/1] Funding Source: researchfish
- Medical Research Council [MR/J007773/1] Funding Source: researchfish
- ESRC [ES/N000323/1] Funding Source: UKRI
- MRC [MR/J007773/1] Funding Source: UKRI
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DNA methylation provides an attractive possible means for propagating the effects of environmental inputs during fetal life and impacting subsequent adult mental health, which is leading to increasing collaboration between molecular biologists, nutritionists and psychiatrists. An area of interest is the potential role of folate, not just in neural tube closure in early pregnancy, but in later major neurodevelopmental events, with consequences for later sociocognitive maturation. Here, we set the scene for recent discoveries by reviewing the major events of neural development during fetal life, with an emphasis on tissues and structures where dynamic methylation changes are known to occur. Following this, we give an indication of some of the major classes of genes targeted by methylation and important for neurological and behavioral development. Finally, we highlight some cognitive disorders where methylation changes are implicated as playing an important role.
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