Journal
EPIGENOMICS
Volume 8, Issue 8, Pages 1087-1101Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2016-0034
Keywords
epigenetics; fibrosis; HDAC inhibitors; histone acetylation; post-translational; modifications; valproic acid
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Funding
- National Institute of Pharmaceutical Education and Research, S.A.S. Nagar, Mohali, India
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Tissue injuries and pathological insults produce oxidative stress, genetic and epigenetic alterations, which lead to an imbalance between pro- and anti-fibrotic molecules, and subsequent accumulation of extracellular matrix, thereby fibrosis. Various molecular pathways play a critical role in fibroblasts activation, which promotes the extracellular matrix production and accumulation. Recent reports highlighted that histone deacetylases (HDACs) are upregulated in various fibrotic disorders and play a central role in fibrosis, while HDAC inhibitors exert antifibrotic effects. Valproic acid is a first-line anti-epileptic drug and a proven HDAC inhibitor. This review provides the current research and novel insights on antifibrotic effects of valproic acid in various fibrotic conditions with an emphasis on the possible strategies for treatment of fibrosis.
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