Journal
EPIGENOMICS
Volume 8, Issue 6, Pages 817-829Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2016-0005
Keywords
cell-specific epigenomes; ChIP-seq; DNA methylation; environmental epigenetics; epigenomics; histone modification; lung; organ
Categories
Funding
- Hastings and Whittier Foundations
- Department of Defense [W81XWH1410174]
- NIH [R01 HL114094, P30 H101258, R01HL112638, 4 R37HL062569, 1R01HL114959]
- Norris comprehensive Cancer Center core from the National Cancer Institute [P30CA0189]
- National Institute of Environmental Health Sciences (NIEHS) [NIH T32ES013678]
- USC Provost's Postdoctoral Scholar Research Grant
- ACS/Canary postdoctoral fellowship [R01 HL114094, PFTED-10-207-01-SIED]
- Department of Surgery
- Canary and Thomas G. Labrecque Foundations
- U.S. Department of Defense (DOD) [W81XWH1410174] Funding Source: U.S. Department of Defense (DOD)
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The human body consists of hundreds of kinds of cells specified from a single genome overlaid with cell type-specific epigenetic information. Comprehensively profiling the body's distinct epigenetic landscapes will allow researchers to verify cell types used in regenerative medicine and to determine the epigenetic effects of disease, environmental exposures and genetic variation. Key marks/factors that should be investigated include regions of nucleosome-free DNA accessible to regulatory factors, histone marks defining active enhancers and promoters, DNA methylation levels, regulatory RNAs, and factors controlling the three-dimensional conformation of the genome. Here we use the lung to illustrate the importance of investigating an organ's purified cell epigenomes, and outline the challenges and promise of realizing a comprehensive catalog of primary cell epigenomes.
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