Journal
EPIGENOMICS
Volume 8, Issue 1, Pages 67-75Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/epi.15.95
Keywords
biomarkers; CpG dinucleotides; epigenomics; epigenetics; Epstein-Barr virus; hepatitis B virus; methylation
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Funding
- Council of Scientific and Industrial Research (CSIR) [GENESIS-BSC0121]
- Department of Bio-technology, Government of India [GAP0001]
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Aims: To develop a computational resource for viral epigenomic methylation profiles from diverse diseases. Materials & methods: Methylation patterns of Epstein-Barr virus and hepatitis B virus genomic regions are provided as web platform developed using open source Linux-Apache-MySQL-PHP (LAMP) bundle: programming and scripting languages, that is, HTML, javascript and PERL. Results: A comprehensive and integrated web resource ViralEpi v1.0 is developed providing well-organized compendium of methylation events and statistical analysis associated with several diseases. Additionally, it also facilitates 'Viral EpiGenome Browser' for user-affable browsing experience using JavaScript-based JBrowse. Conclusion: This web resource would be helpful for research community engaged in studying epigenetic biomarkers for appropriate prognosis and diagnosis of diseases and its various stages.
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