Journal
ACS MEDICINAL CHEMISTRY LETTERS
Volume 7, Issue 12, Pages 1087-1091Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsmedchemlett.6b00293
Keywords
Micro-organogels; on-demand drug delivery; gold nanorods; near-infrared; flurbiprofen
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Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [NRF-2013R1A1A1076019]
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In this study, we designed a biocompatible drug carrier: micro-organogels prepared by emulsification using vegetable oils and self-assembled gelator fibers. Flurbiprofen was chosen as a hydrophobic model drug and is classified as a nonsteroidal anti-inflammatory drug. In the absence of NIR light, flurbiprofen encapsulated in micro-organogels with gold nanorods (GNRs) was released slowly, while release was accelerated in the presence of NIR light due to the increase in the temperature surrounding the GNRs that transforms the gels into liquid. These results suggest that our system can be efficiently used as a versatile scaffold for on-demand drug delivery systems.
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