Journal
ACS MEDICINAL CHEMISTRY LETTERS
Volume 7, Issue 9, Pages 847-851Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsmedchemlett.6b00215
Keywords
Protein arginine deiminases; small molecule inhibitor; apoptosis inducing factor; spinal cord injury
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Funding
- NIH [R01-GM054051]
- NIH Chemical Biology training grant [5T32 GM7499-34]
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The protein arginine deiminases (PADs) catalyze the post-translational deimination of arginine side chains. Multiple PAD isozymes have been characterized, and abnormal PAD activity has been associated with several human disease states. PAD3 has been characterized as a modulator of cell growth via apoptosis inducing factor and has been implicated in the neurodegenerative response to spinal cord injury. Here, we describe the design, synthesis, and evaluation of conformationally constrained versions of the potent and selective PAD3 inhibitor 2. The cell activity of representative inhibitors in this series was also demonstrated for the first time by rescue of thapsigargin-induced cell death in PAD3-expressing HEK293T cells.
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