Journal
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
Volume 9, Issue 1, Pages 67-76Publisher
SPRINGER
DOI: 10.1007/s12265-015-9668-7
Keywords
Autonomic modulation; Vagal nerve stimulation; Heart failure; Cardiac remodeling; Heart rate; Parasympathetic nervous system; Vagus nerve
Funding
- Boston Scientific
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This study investigated whether vagal nerve stimulation (VNS) leads to improvements in ischemic heart failure via heart rate modulation. At 7 +/- 1 days post left anterior descending artery (LAD) ligation, 63 rats with myocardial infarctions (MI) were implanted with ECG transmitters and VNS devices (MI + VNS, N = 44) or just ECG transmitters (MI, N = 17). VNS stimulation was active from 14 +/- 1 days to 8 +/- 1 weeks post MI. The average left ventricular (LV) end diastolic volumes at 8 +/- 1 weeks were MI = 672.40 mu l and MI + VNS = 519.35 mu l, p = 0.03. The average heart weights, normalized to body weight (+/- std) at 14 +/- 1 weeks were MI = 3.2 +/- 0.6 g*kg(-1) and MI + VNS = 2.9 +/- 0.3 g*kg(-1), p = 0.03. The degree of cardiac remodeling was correlated with the magnitude of acute VNS-evoked heart rate (HR) changes. Further research is required to determine if the acute heart rate response to VNS activation is useful as a heart failure biomarker or as a tool for VNS therapy characterization.
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