Journal
CELL DEATH & DISEASE
Volume 7, Issue -, Pages -Publisher
SPRINGERNATURE
DOI: 10.1038/cddis.2016.272
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Funding
- National Natural Science Foundation of China [81460440, 81372322]
- Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University [2014FB059]
- Scientific Research Projects from Internal Research Institutions of Medical and Health Units in Yunnan Province [2014NS013, 2014NS014, 2014NS015, 2014NS016]
- Foundation of the Yunnan Provincial Innovative Team of Bone and Soft Tissue Tumor [2015HC026]
- Foundation of the Young and Middle-aged Academic and Technical Leaders of Yunnan Province [2014HB034]
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Long noncoding RNAs (lncRNAs) are a class of non-protein-coding molecules longer than 200 nucleotides that are involved in the development and progression of many types of tumors. Numerous lncRNAs regulate cell proliferation, metastasis, and chemotherapeutic drug resistance. Osteosarcoma is one of the main bone tumor subtypes that poses a serious threat to adolescent health. We summarized how lncRNAs regulate osteosarcoma progression, invasion, and drug resistance, as well as how lncRNAs can function as biomarkers or independent prognostic indicators with respect to osteosarcoma therapy.
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