Journal
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
Volume 8, Issue 8, Pages -Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a018937
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Funding
- University of North Carolina (UNC) start-up fund
- National Alliance for Research on Schizophrenia and Depression (NARSAD)
- American Heart Association
- Whitehall Foundation
- National Institutes of Health (NIH) [R21MH106939]
- UNC Pharmacology T32 Training Grant
- Simons Foundation Autism Research Initiative (SFARI)
- NIH [NS048271, HD069184, NS047344, ES021957]
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- Maryland Stem Cell Research Fund
- Foundation's Parkinson's Disease Program [H-1]
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The adult mammalian brain is a dynamic structure, capable of remodeling in response to various physiological and pathological stimuli. One dramatic example of brain plasticity is the birth and subsequent integration of newborn neurons into the existing circuitry. This process, termed adult neurogenesis, recapitulates neural developmental events in two specialized adult brain regions: the lateral ventricles of the forebrain. Recent studies have begun to delineate how the existing neuronal circuits influence the dynamic process of adult neurogenesis, from activation of quiescent neural stem cells (NSCs) to the integration and survival of newborn neurons. Here, we review recent progress toward understanding the circuit-based regulation of adult neurogenesis in the hippocampus and olfactory bulb.
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