Journal
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
Volume 8, Issue 5, Pages -Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a019372
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Funding
- la Ligue Nationale contre le Cancer
- European Commission Network of Excellence EpiGeneSys
- European Research Council
- Agence Nationalc de la Recherche (ANR)
- Israel Science Foundation
- Lew Sanders
- Norton Herrick
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The genome is subject to a diverse array of epigenetic modifications from DNA methylation to histone posttranslational changes. Many of these marks are somatically stable through cell division. This article focuses on our knowledge of the mechanisms governing the inheritance of epigenetic marks, particularly, repressive ones, when the DNA and chromatin template are duplicated in S phase. This involves the action of histone chaperones, nucleosome-remodeling enzymes, histone and DNA methylation binding proteins, and chromatin-modifying enzymes. Last, the timing of DNA replication is discussed, including the question of whether this constitutes an epigenetic mark that facilitates the propagation of epigenetic marks.
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