Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 27, Issue -, Pages 570-588Publisher
ELSEVIER
DOI: 10.1016/j.jff.2016.10.008
Keywords
Cocoa polyphenols; Antioxidants; Oxidative stress; Chronic diseases; Health beneficial effect
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Funding
- Spanish Ministry of Science and Innovation (MICINN) [AGL2015-67087-R, AGL2014-58205-REDC]
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Oxidative stress has been related to the pathogenesis of chronic diseases. Therefore, prevention of these pathologies by avoiding the damaging effects of free radicals and oxidants has become an important potential chemopreventive and therapeutic approach. In this line, epidemiologic studies have demonstrated that dietary antioxidants seem to play a main role in the prevention of chronic diseases caused by oxidative stress, such as cancer, cardiovascular disease and diabetes. Indeed, cocoa and its flavanols can interfere in the initiation and progression of the mentioned diseases through different mechanisms. This review summarises recent progress on the health benefits of cocoa and its flavanols associated to the antioxidant effects, and discusses their potential molecular mechanism of action in the prevention and/or treatment of relevant chronic diseases. (C) 2016 Elsevier Ltd. All rights reserved.
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