Oxyresveratrol: A bioavailable dietary polyphenol

To evaluate the potential of oxyresveratrol (OXY), a dietary polyphenol with various health promoting activities as a nutraceutical/functional food ingredient, its absolute oral bioavailability (F) was examined in Sprague-Dawley rats. Upon single intravenous administration (15 mu mol/kg), rapid clearance (Cl) and short mean transit time (MTT) was observed. Dose-escalation to 90 mu mol/kg did not alter its Cl and MTT significantly. After single oral administration (100 mu mol/kg), although its F was only similar to 10%, OXY was absorbed rapidly and displayed long residence in systemic circulation. Dose-escalation to 400 mu mol/kg brought similar to 60% and 100% increase in F and dose-normalized maximal plasma concentration (C-max), respectively. One-week daily dosing (100 mu mol/kg) did not cause substantial change in F and C-max. Although OXY possessed slower Cl, its oral plasma exposure was comparable to RES. As OXY was orally bioavailable, further development of OXY as a nutraceutical/functional food ingredient is warranted. (C) 2016 Elsevier Ltd. All rights reserved.