Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 25, Issue -, Pages 302-313Publisher
ELSEVIER
DOI: 10.1016/j.jff.2016.06.003
Keywords
Gastroprotective activity; Ethanol-induced gastric injury; Oxidative stress; Apoptosis; LUT7G; Ophiorrhiza mungos
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Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2014R1A1A2055893]
- Deanship of Scientific Research, King Saud University [RG-1435-045]
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The gastroprotective effect of luteolin-7-O-glucoside (LUT7G) on different ulcer models using rats including the indomethacin model, the ethanol-induced gastric ulcer model and the Shay ulcer model was examined. The ethanol-induced ulcer group showed significant increases in MPO, NO, iNOS, MMP-2, MMP-9, caspase-3, apoptosis, IL-6, TNF-alpha, IKK, NF-kappa B, p65, and ICAM-1 and declines in PGE2, arginase, SOD, GSH, mucin, IL-10, eNOS, COX-1, HSP-70, and I kappa B alpha levels. However, LUT7G (25 mg/kg) pretreatment significantly reverted the pathophysiological levels of these biomarkers to near normal levels. The gastroprotective activity of LUT7G was abolished by pretreatment with SC560, rofecoxib, and L-NAME, demonstrating the participation of COX and NOS in LUT7G-facilitated gastroprotection against ethanol induced ulcers. Convincingly, LUT7G (25 mg/kg) provided protective effects in the rat gastric mucosa against ethanol-induced gastric injury at least in part to antisecretory, anti-inflammatory, antioxidative, and antiapoptotic activity, and augmentation of PGE2, mucin and HSP-70 synthesis. (C) 2016 Elsevier Ltd. All rights reserved.
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