Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 25, Issue -, Pages 186-196Publisher
ELSEVIER
DOI: 10.1016/j.jff.2016.05.011
Keywords
Type 2 diabetic rat; Deoiled cumin; Dietary fibre; Biochemical parameters; Histopathological analysis
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Funding
- Earmarked Fund for Comprehensive Utilization and Deep Processing of Cumin and Related Byproducts [2014-Z64]
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The effects of soluble dietary fibre (SDF) and insoluble dietary fibre (IDF) from deoiled cumin on low-dose streptozotocin and high glucose-fat-induced type 2 diabetes rats were examined. Male Wistar rats were divided into nine groups: control (non-diabetic, no SDF or IDF intake), model (diabetes only), metformin, high-dose SDF (5 g/kg body weight), middle dose SDF (500 mg/kg body weight), low-dose SDF (250 mg/kg body weight), high-dose IDF (5 g/kg body weight), middle-dose IDF (500 mg/kg body weight), and low-dose IDF (250 mg/kg body weight). SDF treatments, in particular, middle-dose SOF for 4 weeks, induced better regulation of blood glucose, insulin, hormones, and liver lipid metabolism in diabetic rats, accompanied by increased levels of short-chain fatty acids in colon and decreased fatty degeneration of liver. Our results collectively support the therapeutic potential of SDF from deoiled cumin in type 2 diabetes. (C) 2016 Published by Elsevier Ltd.
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