Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 23, Issue -, Pages 565-572Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2016.03.011
Keywords
Melicope pteleifolia; Chroman; Quinoline; Alkaloids; Neurite outgrowth
Categories
Funding
- National Natural Science Foundation of China [21372125]
- Ministry of Science & Technology 973 Project [2014CB560709]
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Bioactive substances that promote neurite outgrowth and prevent neuronal degeneration are potentially useful for the medical treatment of Alzheimer's disease (AD). This study aimed to obtain bioactive compounds from the stems of the medicinal and edible plant Melicope pteleifolia that promote neurite outgrowth. A bioassay-guided phytochemical investigation led to the isolation of four new chroman derivatives, pteleifolones A D (1-4), and nine known components, acronyculatin B (5), acronylin (6), marmesin (7), 5-methoxymarmesin (8), (+)-peucedanol (9), atanine (10), N-methylatanine (11), dictamnine (12), and evolitrine (13). Their structures were established by extensive nuclear magnetic resonance (NMR) spectroscopic data analysis. Most of these compounds promoted nerve growth factor (NGF)-mediated neurite outgrowth in PC12 cells. These chemical and biological results provide a basis for the further development and utilization of M. pteleifolia as a functional food. (C) 2016 Elsevier Ltd. All rights reserved.
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