Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 22, Issue -, Pages 257-269Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2016.01.029
Keywords
Spent hops; Humulus lupulus L.; Endothelium; Blood platelet; CD39; Cardiovascular disorders
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Funding
- grant Production of polyphenol extracts of plant origin with antiplatelet and cardioprotective properties - FLAWOPIRYNA - European Union from the European Regional Development Fund [UDA-POIG.01.03.01-10-129/08-00]
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Spent hop extract (SHE) is hypothesized to possess multifaceted anticoagulant effect and to reduce platelet reactivity in a direct manner and to improve the antiplatelet action of endothelium. The results demonstrated that SHE, rich in flavanols (50% of total phenolic compounds), hydroxycinnamic acids, proanthocyanidin oligomers, flavan-3-ol monomers, and flavonol glycosides, inhibited ADP-induced platelet aggregation up to 11% for 7.5 mu g/ml or up to 23% for 15 mu g/ml, P < 0.05. Additionally, SHE ameliorated anticoagulant activity of human endothelial cells to significantly reduce platelet reactivity. This effect could be related to the increased expression/activity of the ecto-ADPase (CD39). ADP-induced platelet reactivity was reduced in the case of platelets incubated with the extract-treated endothelial cells compared to the untreated cells. Diabetic rats fed with SHE demonstrated longer survival time than the group treated with placebo. In conclusion, our study provided evidence for a potential beneficial role of SHE in the regulation of platelet and endothelial function. (C) 2016 Elsevier Ltd. All rights reserved.
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