Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 27, Issue -, Pages 178-188Publisher
ELSEVIER
DOI: 10.1016/j.jff.2016.09.005
Keywords
Coreopsis tinctoria; Flavonoid glycoside; Flavonoid aglycone; Pharmacoldnetic profile; Deglycosylation
Categories
Funding
- Zhejiang Administration of Traditional Chinese Medicine of China [2016ZZ014]
- Zhejiang Provincial Science and Technology Foundation of China [2015C33162]
- International Science & Technology Cooperation Program of China [2014DFE30050]
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Marein, flavanomarein and taxifolin-7-O-beta-D-glucopyranoside (TDG) are functional compounds in capitula of Coreopsis tinctoria (CCT). This study demonstrated the above glycosides could be partially deglycosylated to okanin, isookanin and taxifolin, respectively, in cell free extracts from rat and human small intestine, human colon, but not from stomach and cecum. Okanin and isookanin mainly occurred as glucuronide conjugates; whereas taxifolin was in sulfate in rat plasma. The exposures of the glycosides and aglycones were positively correlated with the dosages of CCT extract in rats after oral administration. The aglycones but not glycosides were detected in the plasma of healthy volunteers after intake of CCT (2.5 g/50 kg) water solution. In conclusion, marein, flavanomarein and TDG could be deglycosylated to respective aglycones in gastrointestinal tracts, which could be absorbed and biotransformed to glucuronide or sulfate conjugates. The results will help us to better understand the function and functional components of CCT in vivo. (C) 2016 Elsevier Ltd. All rights reserved.
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