Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 20, Issue -, Pages 516-531Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2015.11.029
Keywords
Pacific oyster; Obesity; Insulin resistance; Polyphenol; Antioxidant
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Funding
- Japan Society for the Promotion of Science [25450297]
- Regional Innovation Strategy Support Program of the MEXT (Ministry of Education, Culture, Sports, Science, and Technology, Japan)
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The phenolic compound 3,5-dihydroxy-4-methoxybenzyl alcohol (DHMBA) is a natural antioxidant recently isolated from the Pacific oyster. DHMBA, up to a concentration of 500 mu M, has demonstrated a strong in vitro hepatocyte-protective effect from oxidative stress without any cytotoxicity. This study investigated the in vivo potential of DHMBA-rich oyster extracts (DOE) for prevention or attenuation of non-alcoholic steatohepatitis (NASH). NASH-model mice, developed by supplementation of a high-fat diet for 23 weeks and intravenous injections of oxidised low-density lipoproteins, exhibited obesity, insulin resistance, hepatic steatosis, inflammation, fibrosis, and apoptosis. These changes were significantly moderated by supplementation of DOE. The search for an underlying mechanism determined that DOE significantly improved the redox status of DNA, proteins, and lipids. Moreover, DOE suppressed the increase of hepatic expression of PPARy and CD36 (fatty acid transporter) in the NASH-model mice. DOE might serve as a functional food for people at elevated risk for NASH. (C) 2015 The Authors. Published by Elsevier Ltd.
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