Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 20, Issue -, Pages 443-452Publisher
ELSEVIER
DOI: 10.1016/j.jff.2015.11.028
Keywords
Hepatic steatosis; Insulin resistance; NAFLD; NASH; DHA; Trans fatty acid
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Funding
- USDA/ARS (CRIS) [5306-51530-017-00D]
- National Natural Science Foundation of China (NSFC) [81272436]
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It has been shown that docosahexaenoic acid (DHA) prevents nonalcoholic fatty liver disease (NAFLD) and insulin resistance (IR) caused by conjugated linoleic acid (CLA), a trans fatty acid (TFA). Here, we evaluated whether DHA will reverse existing CLA-induced NAFLD and IR in mice. DHA-specific effects on existing NAFLD involved significant (P < 0.005) lowering of hepatic weight and triacylglycerol content and expression of genes involved in fatty acid synthesis, enhancing expression of genes involved in fatty acid oxidation, and increasing serum adiponectin levels. Also, immunohistochemistry showed lower expression of hepatic CD163 (inflammation) and smooth muscle a-actin (fibrosis). Compared to the CLA diet, mice fed DHA and control diets had significantly (P < 0.05) lower serum insulin and ALT activity, but only DHA had lower (P = 0.05) expression of genes involved in fibrosis. DHA supplementation for 4 weeks reversed already existing hepatic steatosis, inflammation, and fibrosis caused by CLA. Published by Elsevier Ltd.
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