Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 26, Issue -, Pages 187-195Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2016.07.013
Keywords
Secoisolariciresinol diglucoside; Ulcerative colitis; Dextran sulphate sodium; Inflammation; Mucosal permeability
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Funding
- National Natural Science Foundation of China [NSFC-31171681, NSFC-31271856]
- Agricultural Science and Technology Innovation Project of Chinese Academy of Agricultural Sciences [CAAS-ASTIP-2013-OCRI]
- earmarked fund for Modern Agro-industry Technology Research System, China [CARS-17]
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The effect of flaxseed lignan secoisolariciresinol diglucoside (SDG) on ulcerative colitis was examined. Experimental colitis was induced in mice by administering 5% dextran sulphate sodium (DSS). SDG in doses of 100 and 200 mg/kg/day and 5-aminosalicylic acid (positive control) were given orally for 3 days before and during DSS administration. Oral SDG treatment significantly decreased the disease activity index and increased colon length. Histological examination revealed that the oral administration of SDG suppressed DSS-induced erosion, ulceration, crypt abscesses and oedema. Furthermore, colonic myeloperoxidase activity and TNF-alpha expression declined remarkably following treatment with SDG. Additionally, oral SDG treatment significantly increased the expression of several mucoprotection markers, to include zona occludens-1, Tollip and trefoil factor 3, and thus restored intestinal permeability. These results suggested that oral SDG treatment can alleviate DSS-induced colitis and might be a promising supplement for the amelioration of inflammatory bowel disease. (C) 2016 Elsevier Ltd. All rights reserved.
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