Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 27, Issue -, Pages 448-460Publisher
ELSEVIER
DOI: 10.1016/j.jff.2016.10.003
Keywords
Wine; Grape; Polyphenol; Cardiovascular disease; Endothelial function; Blood pressure
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Funding
- Unilever R&D Vlaardingen B.V
- Netherlands Heart Foundation [2009T064]
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In a randomized double-blind crossover trial, the effect of 8 week supplementation with grape and wine polyphenols on functional and structural vascular parameters and autonomic activity was evaluated in 40 essential hypertensive patients treated with diuretic monotherapy. Ambulatory blood pressure, brachial artery flow mediated dilation (FMD) and pulse-wave velocity (PWV) were measured at baseline and after each 8-week intervention. Forearm resistance artery endothelial function and muscle sympathetic nerve activity (MSNA) response to mental stress and cold-pressor test were measured in two separate subgroups. No statistically significant differences were found across time or between groups in either blood pressure, FMD, PWV, or resistance artery endothelial function. The MSNA response to the two stressors was non-significantly attenuated after grape-wine polyphenol supplementation. These results do not support the hypothesis that daily consumption of a high dose of grape and wine polyphenols lowers blood pressure or affects vascular function in patients already on antihypertensive medication. (C) 2016 Elsevier Ltd. All rights reserved.
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