Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 26, Issue -, Pages 77-87Publisher
ELSEVIER
DOI: 10.1016/j.jff.2016.07.004
Keywords
Comelian cherry fruits; Phenolic compounds; Antioxidant activity; Anti-inflammatory effects
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Funding
- Ministry of Education and Scientific Research, Romania [147/2011 PN-II-PT-PCCA-2011-3-1-0914]
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The biological activity of Cornus mas fruits (CM) on acute inflammation in relation to the in vitro antioxidant properties was investigated. The in vitro antioxidant activity was evaluated by ferric reducing ability of plasma (FRAP) and by the 2,2'-azinobis-3-ethyl-benzthiazino-6-sulphonic acid (ABTS) test. The high-performance liquid chromatography (HPLC) profile of CM extract revealed the presence of 10 main phenolic compounds. The anti-inflammatory effect of CM extract was evaluated by analysing the cytokine levels in the soft paw tissue of Wistar rats after inducing inflammation. CM extract showed potent in vitro antioxidant activity and also led to significant suppression of interleukin (IL)-1 beta and IL-13 production in paw tissue, enhancing the production of IL-10. The histopathological investigation of paw and liver samples revealed that low dose of CM extract attenuated the initial acute inflammatory reaction while high dose inhibited the exudation of inflammatory cells to the inflammation site. (C) 2016 Elsevier Ltd. All rights reserved.
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