Journal
BIOSCIENCE TRENDS
Volume 10, Issue 3, Pages 188-196Publisher
IRCA-BSSA
DOI: 10.5582/bst.2016.01056
Keywords
Vascular endothelial dysfunction; polyphenol; sea buckthorn berries; hyperlipidemia; protection
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Funding
- Special Fund for the International Scientific and Technological Cooperation Program [2014DFA31020]
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Chronic hyperlipemia increases the incidence of vascular endothelial dysfunction and can even induce cardiovascular disease. Sea buckthorn contains a host of bioactives such as flavonoids and polyphenols that can prevent the development of cardiovascular disease. The current study isolated active ingredients, polyphenols, from sea buckthorn berries (SVP) and orally administered SVP at a dose of 7-28 mg/kg. This treatment significantly reduced serum lipids, it enhanced the activity of antioxidant enzymes, and it decreased the level of serum TNF-alpha and IL-6. SVP also alleviate vascular impairment by decreasing the expression of eNOS, ICAM-1, and LOX-1 mRNA and proteins in aortas of rats with hyperlipidemia. Based on these findings, SVP has antioxidant action and it protects endothelium.
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