Journal
ONCOTARGETS AND THERAPY
Volume 9, Issue -, Pages 4705-4714Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/OTT.S88233
Keywords
microRNA; liver cancer; therapeautic target
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Funding
- National Science Foundation of Guangdong Province, People's Republic of China [2014A030310073]
- Guangdong Provincial Science and Technology Plan projects [2009B080701021, 2010B080701021]
- Guangdong Province Public Interest Research and Capacity - Building Projects, People's Republic of China [2014A020212448]
- Guangzhou Science and Technology Plan of Scientific Research Projects, People's Republic of China [201510010286]
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Background/aim: Increasing evidence show microRNAs (miRNAs) are engaged in hepatocellular carcinoma (HCC). The aim of this study was to investigate the role of miR-144 in HCC, as well as to identify its underlying mechanism. Methods: The expression levels of miR-144 were assessed in multiple HCC cell lines, as well as in liver tissues from patients with HCC. We further examined the effects of miR-144 on HCC. The molecular target of miR-144 was identified using a computer algorithm and confirmed experimentally. Results: We found that the levels of miR-144 were frequently downregulated in human HCC tissues and cell lines, and overexpression of miR-144 dramatically inhibited HCC metastasis, invasion, cell cycle, epithelial-mesenchymal transition, and chemoresistance. We further verified the SMAD4 as a novel and direct target of miR-144 in HCCs. Conclusion: Taken together, overexpression of miR-144 or downregulation of SMAD4 may prove beneficial as therapeutic strategies for HCC treatment.
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