Journal
ONCOTARGETS AND THERAPY
Volume 9, Issue -, Pages 6297-6304Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/OTT.S110295
Keywords
endocan; ESM-1; biomarker; cancer; prognosis; meta-analysis
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Funding
- Natural Science Foundation of China [81672869]
- National Science Foundation for Young Scholars [81302013]
- Jiangsu Provincial Science Foundation [BK20161596]
- Jiangsu Provincial Six talent peak of Human affair Hall Funding [2013-WSW-037]
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Endocan is a 50 kDa dermatan sulfate proteoglycan. Numerous previous studies have indicated that endocan might be an attractive prognostic tumor biomarker. However, the results of different studies are inconsistent. We conducted a meta-analysis to explore the association between endocan expression and cancer prognosis. A systematic, comprehensive search of the PubMed, Embase, and China National Knowledge Infrastructure databases was performed. Expression of endocan and its association with overall survival were evaluated by pooled hazard ratios (HRs) and their 95% confidence intervals (CIs). In total, 15 eligible studies of 1,464 patients were finally included in this meta-analysis. A significant association was found between elevated endocan expression and poorer overall survival (pooled HR: 2.48, 95% CI: 2.12-2.90, P<0.001). In the cancer-type subgroup, significant associations were detected for gastrointestinal (HR: 2.27, 95% CI: 1.77-2.91, P<0.001) and hepatocellular (HR: 2.61, 95% CI: 1.96-3.48, P<0.001) carcinoma. Our results demonstrate that endocan could be useful to exploit as a novel prognostic biomarker for patients with cancer.
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